Thyroid. 2005 Jun;15(6):511-21.

Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1.

Chen H, Kunnimalaiyaan M, Van Gompel JJ.

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Department of Surgery, University of Wisconsin Medical School, the University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, USA. chen@surgery.wisc.edu

Abstract

Medullary thyroid cancer (MTC) is a prototypic neuroendocrine tumor of the thyroid C cells. Other than surgery, there are no curative therapies for MTC. In this review, we detail recent studies that suggest that targeting specific signaling pathways may be a viable strategy to control MTC tumor progression. Specifically, we discuss the role of the raf-1 and achaete-scute homologue-1 pathways in the MTC tumor growth and differentiation.

PMID:: 16029117; [PubMed - indexed for MEDLINE]

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