Scand J Gastroenterol. 2005 Apr;40(4):477-81.

Ménétrier's disease in a patient with Helicobacter pylori infection is linked to elevated glucagon-like peptide-2 activity.

Watanabe K, Beinborn M, Nagamatsu S, Ishida H, Takahashi S.

Source

Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. kaz@kyorin-u.ac.jp

Abstract

This report focuses on a 59-year-old male Japanese patient with Ménétrier's disease who suffered from severe hypoproteinemia and tested positive for Helicobacter pylori when initially admitted to hospital. Blood levels of intact glucagon-like peptide-2 (GLP-2) were determined by specific bioassay, using serum-induced cAMP production in COS-7 cells expressing recombinant human GLP-2 receptors as a functional readout. Eradication of H. pylori led to remission of Ménétrier's disease as well as a partial yet significant decrease in GLP-2 levels, and also improved hypoproteinemia. These observations suggest a possible link between excess systemic endogenous production of GLP-2, a gut hormone that induces mucosal growth, and the hypertrophic gastropathy in a Ménétrier's disease patient with H. pylori infection.

PMID:: 16028444; [PubMed - indexed for MEDLINE]

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