J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):13-9. Epub 2005 Jul 18.

The Vitamin D requirement in health and disease.

Source

Creighton University, 601 N. 30th St., Suite 4841 Omaha, NE 68131, USA. rheaney@creighton.edu

Abstract

Advances in Vitamin D nutritional physiology since publication of the DRIs in 1997 are briefly summarized. Available data indicate that (1) Vitamin D's canonical function, optimizing intestinal calcium absorption, is fully expressed at serum 25-hydroxyvitamin D (25OHD) concentration of approximately 80nmol/L; (2) elevated parathyroid activity, typical of aging populations, is minimized at the same 25OHD value and (3) osteoporotic fractures are reduced when serum 25OHD is raised to near 80nmol/L. Depending upon starting value, achieving 25OHD concentrations of 80 or higher may require a daily oral intake of 2200IU (55microg) or more in addition to prevailing cutaneous inputs. The tolerable upper intake level (TUIL), currently set at 2000IU (50microg)/day, is too low to permit optimization of Vitamin D status in the general population. Actual toxicity is not seen below serum 25OHD values of 250nmol/L, a value that would be produced only at continuing oral intakes in excess of 10,000IU (250microg)/day.

PMID:: 16026981; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Vitamin D - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. [J Am Coll Nutr. 2003]
Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D.
Heaney RP, Dowell MS, Hale CA, Bendich A. J Am Coll Nutr. 2003 Apr; 22(2):142-6.
Vitamin D2 dose required to rapidly increase 25OHD levels in osteoporotic women. [Eur J Clin Nutr. 2006]
Vitamin D2 dose required to rapidly increase 25OHD levels in osteoporotic women.
Mastaglia SR, Mautalen CA, Parisi MS, Oliveri B. Eur J Clin Nutr. 2006 May; 60(5):681-7.
Review Effectiveness and safety of vitamin D in relation to bone health. [Evid Rep Technol Assess (Full ...]
Review Effectiveness and safety of vitamin D in relation to bone health.
Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, et al. Evid Rep Technol Assess (Full Rep). 2007 Aug; (158):1-235.
Vitamin D status of patients admitted to a hospital rehabilitation unit: relationship to function and progress. [Am J Phys Med Rehabil. 2007]
Vitamin D status of patients admitted to a hospital rehabilitation unit: relationship to function and progress.
Kiebzak GM, Moore NL, Margolis S, Hollis B, Kevorkian CG. Am J Phys Med Rehabil. 2007 Jun; 86(6):435-45.
Review [New definition of optimal vitamin D status and redefening serum parathyroid hormone reference range]. [Rev Med Interne. 2006]
Review [New definition of optimal vitamin D status and redefening serum parathyroid hormone reference range].
Cormier C, Souberbielle JC. Rev Med Interne. 2006 Sep; 27(9):684-9. Epub 2006 Apr 6.

See reviews... See all...

Cited by 33 PubMed Central articles

Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. [Open Orthop J. 2012]
Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet.
Price CT, Langford JR, Liporace FA. Open Orthop J. 2012; 6:143-9. Epub 2012 Apr 5.
Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer. [J Transl Med. 2012]
Prognostic effects of 25-hydroxyvitamin D levels in gastric cancer.
Ren C, Qiu MZ, Wang DS, Luo HY, Zhang DS, Wang ZQ, Wang FH, Li YH, Zhou ZW, Xu RH. J Transl Med. 2012 Jan 27; 10:16. Epub 2012 Jan 27.
Rediscovering vitamin D. [Libyan J Med. 2010]
Rediscovering vitamin D.
Anaizi N. Libyan J Med. 2010 Nov 8; 5. Epub 2010 Nov 8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The Vitamin D requirement in health and disease.
The Vitamin D requirement in health and disease.
J Steroid Biochem Mol Biol. 2005 Oct ;97(1-2):13-9. Epub 2005 Jul 18 .

PubMed
Calcium alginate immobilized marine microalgae: experiments on growth and short-...
Calcium alginate immobilized marine microalgae: experiments on growth and short-term heavy metal accumulation.
Mar Pollut Bull. 2005 ;51(8-12):823-9. Epub 2005 Jul 18 .

PubMed
Treatment outcome of extensor realignment for patellofemoral dysfunction.
Treatment outcome of extensor realignment for patellofemoral dysfunction.
Knee. 2005 Aug ;12(4):323-8.

PubMed
Bioinformatics approaches for cross-species liver cancer analysis based on micro...
Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling.
BMC Bioinformatics. 2005 Jul 15 ;6 Suppl 2:S6.

PubMed
The effect of manipulation of basal pulsatile insulin on insulin action in Type ...
The effect of manipulation of basal pulsatile insulin on insulin action in Type 2 diabetes.
Diabet Med. 2005 Aug ;22(8):1064-71.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: