Angiotensin II and interleukin-1 interact to increase generation of dopaminergic neurons from neurospheres of mesencephalic precursors

Brain Res Dev Brain Res. 2005 Aug 8;158(1-2):120-2. doi: 10.1016/j.devbrainres.2005.06.009.

Abstract

Cultures of rat mesencephalic precursors treated with interleukin-1beta or angiotensin II contained significantly more dopaminergic neurons than controls. However, simultaneous treatment with angiotensin II and interleukin-1beta did not induce any further increase. Treatment with the angiotensin type-2 receptor antagonist PD 123319 precluded both the angiotensin- and the interleukin-induced increase. The present results indicate that angiotensin type-2 receptors and interleukin-1 cooperate to induce the dopaminergic phenotype.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Angiotensin II / antagonists & inhibitors
  • Angiotensin II / pharmacology*
  • Animals
  • Cell Count / methods
  • Cells, Cultured
  • Dopamine / metabolism*
  • Drug Interactions
  • Embryo, Mammalian
  • Glial Fibrillary Acidic Protein / metabolism
  • Imidazoles / pharmacology
  • Interleukin-1 / pharmacology*
  • Mesencephalon / cytology*
  • Naphthyridines / pharmacology
  • Neurons / drug effects*
  • Neurons / metabolism
  • Pyridines / pharmacology
  • Rats
  • Stem Cells / drug effects*
  • Tubulin / metabolism
  • Tyrosine 3-Monooxygenase / metabolism

Substances

  • Glial Fibrillary Acidic Protein
  • Imidazoles
  • Interleukin-1
  • Naphthyridines
  • Pyridines
  • Tubulin
  • ZD 7155
  • Angiotensin II
  • PD 123319
  • Tyrosine 3-Monooxygenase
  • Dopamine