Abstract
Cultures of rat mesencephalic precursors treated with interleukin-1beta or angiotensin II contained significantly more dopaminergic neurons than controls. However, simultaneous treatment with angiotensin II and interleukin-1beta did not induce any further increase. Treatment with the angiotensin type-2 receptor antagonist PD 123319 precluded both the angiotensin- and the interleukin-induced increase. The present results indicate that angiotensin type-2 receptors and interleukin-1 cooperate to induce the dopaminergic phenotype.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Angiotensin II / antagonists & inhibitors
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Angiotensin II / pharmacology*
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Animals
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Cell Count / methods
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Cells, Cultured
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Dopamine / metabolism*
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Drug Interactions
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Embryo, Mammalian
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Glial Fibrillary Acidic Protein / metabolism
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Imidazoles / pharmacology
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Interleukin-1 / pharmacology*
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Mesencephalon / cytology*
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Naphthyridines / pharmacology
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Neurons / drug effects*
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Neurons / metabolism
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Pyridines / pharmacology
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Rats
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Stem Cells / drug effects*
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Tubulin / metabolism
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Glial Fibrillary Acidic Protein
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Imidazoles
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Interleukin-1
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Naphthyridines
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Pyridines
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Tubulin
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ZD 7155
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Angiotensin II
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PD 123319
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Tyrosine 3-Monooxygenase
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Dopamine