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Ann Med. 2005;37(2):121-9.

HTR2A: association and expression studies in neuropsychiatric genetics.

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  • 1Department of Psychological Medicine, Henry Wellcome Building, Wales School of Medicine, Heath Park, Cardiff CF14 4XN, UK. nortonn@cf.ac.uk


Over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (ADHD), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and Alzheimer's disease (AD). Different studies have tested for genetic association (case-control and family-based studies), protein expression (receptor binding assays), transcriptional expression (mRNA assays) and allelic expression. In this review we examine and summarize these findings in various neuropsychiatric phenotypes.

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