Ann N Y Acad Sci. 2005 Jun;1052:3-10.

Surgical menopause, estrogen, and cognitive function in women: what do the findings tell us?

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Department of Psychology, McGill University, 1205 Dr. Penfield Ave., Montreal, Quebec, Canada H3A 1B1. barbara.sherwin@mcgill.ca

Abstract

Randomized, controlled trials of estrogen treatment found protective effects of estrogen therapy (ET) on verbal memory in healthy, 45-year-old surgically menopausal women given 17-beta estradiol immediately after surgery. However, no effect was found when conjugated equine estrogens were given to older women years after their surgical menopause. These findings suggest that there is a critical time for the initiation of estrogen following the menopause with regard to its protective effect on memory as well as a specificity of the effect on verbal memory. These factors may explain why no protective effect of ET on cognitive aging was found in the Women's Health Initiative Memory Study.

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