J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.

Safayhi H, Mack T, Sabieraj J, Anazodo MI, Subramanian LR, Ammon HP.

Source

Department of Pharmacology, University of Tuebingen, FRG.

Abstract

Isomers (alpha- and beta-) of boswellic acids (BAs), 11-keto-beta-BA and their acetyl derivatives were isolated from the gum resin of Boswellia serrata. BA and derivatives concentration dependently decreased the formation of leukotriene B4 from endogenous arachidonic acid in rat peritoneal neutrophils. Among the BAs, acetyl-11-keto-beta-BA induced the most pronounced inhibition of 5-lipoxygenase (5-LO) product formation with an IC50 of 1.5 microM. In contrast to the redox type 5-LO inhibitor nordihydroguaiaretic acid, BA in concentrations up to 400 microM did not impair the cyclooxygenase and 12-lipoxygenase in isolated human platelets and the peroxidation of arachidonic acid by Fe-ascorbate. The data strongly suggest that BAs are specific, nonreducing-type inhibitors of the 5-LO product formation either interacting directly with the 5-LO or blocking its translocation.

PMID:: 1602379; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Medical

Pain Relievers - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Mechanism of antiinflammatory actions of curcumine and boswellic acids. [J Ethnopharmacol. 1993]
Mechanism of antiinflammatory actions of curcumine and boswellic acids.
Ammon HP, Safayhi H, Mack T, Sabieraj J. J Ethnopharmacol. 1993 Mar; 38(2-3):113-9.
Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues. [J Nat Prod. 2000]
Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.
Schweizer S, von Brocke AF, Boden SE, Bayer E, Ammon HP, Safayhi H. J Nat Prod. 2000 Aug; 63(8):1058-61.
Inhibition by boswellic acids of human leukocyte elastase. [J Pharmacol Exp Ther. 1997]
Inhibition by boswellic acids of human leukocyte elastase.
Safayhi H, Rall B, Sailer ER, Ammon HP. J Pharmacol Exp Ther. 1997 Apr; 281(1):460-3.
Review Modulation of the immune system by Boswellia serrata extracts and boswellic acids. [Phytomedicine. 2010]
Review Modulation of the immune system by Boswellia serrata extracts and boswellic acids.
Ammon HP. Phytomedicine. 2010 Sep; 17(11):862-7. Epub 2010 Aug 8.
Review Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data. [Clin Pharmacokinet. 2011]
Review Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data.
Abdel-Tawab M, Werz O, Schubert-Zsilavecz M. Clin Pharmacokinet. 2011 Jun; 50(6):349-69.

See reviews... See all...

Cited by 19 PubMed Central articles

The effect of Frankincense in the treatment of moderate plaque-induced gingivitis: a double blinded randomized clinical trial. [Daru. 2011]
The effect of Frankincense in the treatment of moderate plaque-induced gingivitis: a double blinded randomized clinical trial.
Khosravi Samani M, Mahmoodian H, Moghadamnia A, Poorsattar Bejeh Mir A, Chitsazan M. Daru. 2011; 19(4):288-94.
Boswellia serrata, a potential antiinflammatory agent: an overview. [Indian J Pharm Sci. 2011]
Boswellia serrata, a potential antiinflammatory agent: an overview.
Siddiqui MZ. Indian J Pharm Sci. 2011 May; 73(3):255-61.
A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. [Int J Med Sci. 2011]
A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee.
Vishal AA, Mishra A, Raychaudhuri SP. Int J Med Sci. 2011; 8(7):615-22. Epub 2011 Oct 12.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
J Pharmacol Exp Ther. 1992 Jun ;261(3):1143-6.

PubMed
Roles and regulation of Wnt signaling and beta-catenin in prostate cancer.
Roles and regulation of Wnt signaling and beta-catenin in prostate cancer.
Cancer Lett. 2006 Jun 8 ;237(1):22-32. Epub 2005 Jul 14 .

PubMed
The challenge of ritualistic child abuse.
The challenge of ritualistic child abuse.
J Child Adolesc Psychiatr Ment Health Nurs. 1992 Apr-Jun ;5(2):37-46.

PubMed
Effect of water-soluble proteoglycan isolated from Agaricus blazei on the matura...
Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells.
Int Immunopharmacol. 2005 Sep ;5(10):1523-32. Epub 2005 Apr 1 .

PubMed
Factors affecting automated syndromic surveillance.
Factors affecting automated syndromic surveillance.
Artif Intell Med. 2005 Jul ;34(3):269-78.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: