Expert Opin Investig Drugs. 2005 Jul;14(7):785-96.

CCR1 antagonists in clinical development.

Source

Biomedical Sciences Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, South Kensington Campus, London SW7 2AZ, UK. j.pease@imperial.ac.uk

Abstract

Chemokines (chemotactic cytokines) are a family of low-molecular-weight proteins that direct the cellular migration of leukocytes by binding to and activating the G protein-coupled receptors displayed on the leukocyte cell surface. The inadvertent or excessive generation of chemokines has been associated with the inflammatory component of several disease processes, and consequently, considerable efforts have been made to characterise chemokine/chemokine receptor interactions with the ultimate aim of therapeutic intervention. This review focuses on the biology of CC chemokine receptor 1, which together with its ligands is thought to recruit leukocytes during the progression of rheumatoid arthritis, multiple sclerosis and organ transplant rejection. The developments made in antagonising this receptor and efficacies of these compounds in the clinical setting are also highlighted.

PMID:: 16022568; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Review CCR1 antagonists for the treatment of autoimmune diseases. [Curr Opin Investig Drugs. 2004]
Review CCR1 antagonists for the treatment of autoimmune diseases.
Gladue RP, Zwillich SH, Clucas AT, Brown MF. Curr Opin Investig Drugs. 2004 May; 5(5):499-504.
Review The clinical potential of chemokine receptor antagonists. [Pharmacol Ther. 2005]
Review The clinical potential of chemokine receptor antagonists.
Ribeiro S, Horuk R. Pharmacol Ther. 2005 Jul; 107(1):44-58.
CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. [J Biol Chem. 2003]
CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.
Gladue RP, Tylaska LA, Brissette WH, Lira PD, Kath JC, Poss CS, Brown MF, Paradis TJ, Conklyn MJ, Ogborne KT, et al. J Biol Chem. 2003 Oct 17; 278(42):40473-80. Epub 2003 Aug 7.
Review CCR1 chemokine receptor antagonist. [Curr Pharm Des. 2003]
Review CCR1 chemokine receptor antagonist.
Saeki T, Naya A. Curr Pharm Des. 2003; 9(15):1201-8.
Review BX471: a CCR1 antagonist with anti-inflammatory activity in man. [Mini Rev Med Chem. 2005]
Review BX471: a CCR1 antagonist with anti-inflammatory activity in man.
Horuk R. Mini Rev Med Chem. 2005 Sep; 5(9):791-804.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Vascular involvement in rheumatic diseases: 'vascular rheumatology'. [Arthritis Res Ther. 2008]
Review Vascular involvement in rheumatic diseases: 'vascular rheumatology'.
Szekanecz Z, Koch AE. Arthritis Res Ther. 2008; 10(5):224. Epub 2008 Oct 10.
Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE. [J Neuroinflammation. 2007]
Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE.
Eltayeb S, Berg AL, Lassmann H, Wallström E, Nilsson M, Olsson T, Ericsson-Dahlstrand A, Sunnemark D. J Neuroinflammation. 2007 May 7; 4:14. Epub 2007 May 7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

CCR1 antagonists in clinical development.
CCR1 antagonists in clinical development.
Expert Opin Investig Drugs. 2005 Jul ;14(7):785-96.

PubMed
Computer-based reading and spelling practice for children with learning disabili...
Computer-based reading and spelling practice for children with learning disabilities.
J Learn Disabil. 1992 Mar ;25(3):186-95.

PubMed
Chronic exertional compartment syndrome: diagnosis and management.
Chronic exertional compartment syndrome: diagnosis and management.
Bull Hosp Jt Dis. 2005 ;62(3-4):77-84.

PubMed
High-throughput screening-driven lead discovery: meeting the challenges of findi...
High-throughput screening-driven lead discovery: meeting the challenges of finding new therapeutics.
Curr Opin Drug Discov Devel. 2005 Jul ;8(4):487-94.

PubMed
A practical comparison of group-sequential and adaptive designs.
A practical comparison of group-sequential and adaptive designs.
J Biopharm Stat. 2005 ;15(4):719-38.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

CCR1 antagonists in clinical development.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information