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The genome of the African trypanosome Trypanosoma brucei.
Berriman M,
Ghedin E,
Hertz-Fowler C,
Blandin G,
Renauld H,
Bartholomeu DC,
Lennard NJ,
Caler E,
Hamlin NE,
Haas B,
Böhme U,
Hannick L,
Aslett MA,
Shallom J,
Marcello L,
Hou L,
Wickstead B,
Alsmark UC,
Arrowsmith C,
Atkin RJ,
Barron AJ,
Bringaud F,
Brooks K,
Carrington M,
Cherevach I,
Chillingworth TJ,
Churcher C,
Clark LN,
Corton CH,
Cronin A,
Davies RM,
Doggett J,
Djikeng A,
Feldblyum T,
Field MC,
Fraser A,
Goodhead I,
Hance Z,
Harper D,
Harris BR,
Hauser H,
Hostetler J,
Ivens A,
Jagels K,
Johnson D,
Johnson J,
Jones K,
Kerhornou AX,
Koo H,
Larke N,
Landfear S,
Larkin C,
Leech V,
Line A,
Lord A,
Macleod A,
Mooney PJ,
Moule S,
Martin DM,
Morgan GW,
Mungall K,
Norbertczak H,
Ormond D,
Pai G,
Peacock CS,
Peterson J,
Quail MA,
Rabbinowitsch E,
Rajandream MA,
Reitter C,
Salzberg SL,
Sanders M,
Schobel S,
Sharp S,
Simmonds M,
Simpson AJ,
Tallon L,
Turner CM,
Tait A,
Tivey AR,
Van Aken S,
Walker D,
Wanless D,
Wang S,
White B,
White O,
Whitehead S,
Woodward J,
Wortman J,
Adams MD,
Embley TM,
Gull K,
Ullu E,
Barry JD,
Fairlamb AH,
Opperdoes F,
Barrell BG,
Donelson JE,
Hall N,
Fraser CM,
Melville SE,
El-Sayed NM.
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK. mb4@sanger.ac.uk
African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei. The 26-megabase genome contains 9068 predicted genes, including approximately 900 pseudogenes and approximately 1700 T. brucei-specific genes. Large subtelomeric arrays contain an archive of 806 variant surface glycoprotein (VSG) genes used by the parasite to evade the mammalian immune system. Most VSG genes are pseudogenes, which may be used to generate expressed mosaic genes by ectopic recombination. Comparisons of the cytoskeleton and endocytic trafficking systems with those of humans and other eukaryotic organisms reveal major differences. A comparison of metabolic pathways encoded by the genomes of T. brucei, T. cruzi, and Leishmania major reveals the least overall metabolic capability in T. brucei and the greatest in L. major. Horizontal transfer of genes of bacterial origin has contributed to some of the metabolic differences in these parasites, and a number of novel potential drug targets have been identified.
PMID: 16020726 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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Gene Conversion Transfers the GAF-A Domain of Phosphodiesterase TbrPDEB1 to One Allele of TbrPDEB2 of Trypanosoma brucei.
Kunz S, Luginbuehl E, Seebeck T.
PLoS Negl Trop Dis. 2009 Jun 9; 3(6):e455. Epub 2009 Jun 9.
[PLoS Negl Trop Dis. 2009]
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Expression and subcellular localization of kinetoplast-associated proteins in the different developmental stages of Trypanosoma cruzi.
Cavalcanti DP, Shimada MK, Probst CM, Souto-Padrón TC, de Souza W, Goldenberg S, Fragoso SP, Motta MC.
BMC Microbiol. 2009 Jun 4; 9:120. Epub 2009 Jun 4.
[BMC Microbiol. 2009]
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Chromosome level assembly of the hybrid Trypanosoma cruzi genome.
Weatherly DB, Boehlke C, Tarleton RL.
BMC Genomics. 2009 Jun 1; 10:255. Epub 2009 Jun 1.
[BMC Genomics. 2009]
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