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Curr Opin Neurobiol. 2005 Aug;15(4):478-87.

Nociceptive processing in the human brain.

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  • 1Department Human Anatomy & Genetics, Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, Oxford OX1 3QX, England, UK.


Since the advent of modern neuroimaging techniques, studies have been carried out to examine nociceptive processing within the human brain non-invasively. Combined with advances in immunohistochemistry, histology and genetics, we have been able to correlate more objective measures of nociceptive processing with the subjective experience that is pain. The result has produced a dramatic shift in our thinking about the neural circuitry involved in nociceptive processing, revealing that pain is much more than a submodality of the sense of touch.

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