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J Intern Med. 2005 Aug;258(2):153-65.

Dietary fat intake and early mortality patterns--data from The Malmö Diet and Cancer Study.

Author information

  • 1Department of Medicine, Lund University, University Hospital (UMAS), Malmö, Sweden. margret.leosdottir@med.lu.se

Abstract

OBJECTIVES:

Most current dietary guidelines encourage limiting relative fat intake to <30% of total daily energy, with saturated and trans fatty acids contributing no more than 10%. We examined whether total fat intake, saturated fat, monounsaturated, or polyunsaturated fat intake are independent risk factors for prospective all-cause, cardiovascular and cancer mortality.

DESIGN:

Population-based, prospective cohort study.

SETTING AND SUBJECTS:

The Malmö Diet and Cancer Study was set in the city of Malmö, southern Sweden. A total of 28,098 middle-aged individuals participated in the study 1991-1996.

MAIN OUTCOME MEASURES:

Subjects were categorized by quartiles of relative fat intake, with the first quartile used as a reference point in estimating multivariate relative risks (RR; 95% CI, Cox's regression model). Adjustments were made for confounding by age and various lifestyle factors.

RESULTS:

Women in the fourth quartile of total fat intake had a significantly higher RR of cancer mortality (RR 1.46; CI 1.04-2.04). A significant downwards trend was observed for cardiovascular mortality amongst men from the first to the fourth quartile (P=0.028). No deteriorating effects of high saturated fat intake were observed for either sex for any cause of death. Beneficial effects of a relatively high intake of unsaturated fats were not uniform.

CONCLUSIONS:

With the exception of cancer mortality for women, individuals receiving more than 30% of their total daily energy from fat and more than 10% from saturated fat, did not have increased mortality. Current dietary guidelines concerning fat intake are thus generally not supported by our observational results.

PMID:
16018792
[PubMed - indexed for MEDLINE]
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