Hum Genet. 1992 May;89(3):329-32.

Protease inhibitor (Pi) locus, fertility and twinning.

Boomsma DI, Frants RR, Bank RA, Martin NG.

Source

Department of Psychonomics, Free University, Amsterdam, The Netherlands.

Abstract

In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an increased frequency of the S allele in fathers of dizygotic twins; however, this may be a secondary effect of assortative mating for family size (indicating by the number of siblings of the parents), for which a correlation of 0.2 was observed. Parents of dizygotic twins came from larger families than parents of monozygotic twins, but no effect of Pi type on family size was seen.

PMID:: 1601424; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

alpha 1-Antitrypsin

LinkOut - more resources

Full Text Sources

EBSCO

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

An excess of the Pi S allele in dizygotic twins and their mothers. [Hum Genet. 1982]
An excess of the Pi S allele in dizygotic twins and their mothers.
Clark P, Martin NG. Hum Genet. 1982; 61(2):171-4.
No paternal effect on monozygotic twinning in the Swedish Twin Registry. [Twin Res. 1998]
No paternal effect on monozygotic twinning in the Swedish Twin Registry.
Lichtenstein P, Källén B, Köster M. Twin Res. 1998 Dec; 1(4):212-5.
alpha1-Antitrypsin deficiency in twins and parents-of-twins. [Clin Genet. 1979]
alpha1-Antitrypsin deficiency in twins and parents-of-twins.
Lieberman J, Borhani NO, Feinleib M. Clin Genet. 1979 Jan; 15(1):29-36.
Review The Twinning and Fertility Paradox. [Prog Clin Biol Res. 1981]
Review The Twinning and Fertility Paradox.
Allen G. Prog Clin Biol Res. 1981; 69A:1-13.
Review Non-identical monozygotic twins, intermediate twin types, zygosity testing, and the non-random nature of monozygotic twinning: a review. [Am J Med Genet C Semin Med Gen...]
Review Non-identical monozygotic twins, intermediate twin types, zygosity testing, and the non-random nature of monozygotic twinning: a review.
Machin G. Am J Med Genet C Semin Med Genet. 2009 May 15; 151C(2):110-27.

See reviews... See all...

Cited by 1 PubMed Central article

Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning. [Hum Reprod. 2008]
Variation in bone morphogenetic protein 15 is not associated with spontaneous human dizygotic twinning.
Zhao ZZ, Painter JN, Palmer JS, Webb PM, Hayward NK, Whiteman DC, Boomsma DI, Martin NG, Duffy DL, Montgomery GW. Hum Reprod. 2008 Oct; 23(10):2372-9. Epub 2008 Jul 9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Protease inhibitor (Pi) locus, fertility and twinning.
Protease inhibitor (Pi) locus, fertility and twinning.
Hum Genet. 1992 May ;89(3):329-32.

PubMed
Indirect comparisons of competing interventions.
Indirect comparisons of competing interventions.
Health Technol Assess. 2005 Jul ;9(26):1-134, iii-iv.

PubMed
Missense mutations and the magnitude of functional deficit: the example of facto...
Missense mutations and the magnitude of functional deficit: the example of factor IX.
Hum Genet. 1992 May ;89(3):295-7.

PubMed
Employment and advice regarding careers for adults with congenital heart disease...
Employment and advice regarding careers for adults with congenital heart disease.
Cardiol Young. 2005 Aug ;15(4):391-5.

PubMed
Building systems of care for youth with serious mental illness.
Building systems of care for youth with serious mental illness.
Hosp Community Psychiatry. 1992 Jun ;43(6):630-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: