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Nat Rev Genet. 2005 Aug;6(8):623-32.

Mapping by admixture linkage disequilibrium: advances, limitations and guidelines.

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  • 1Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA. smithm@ncifcrf.gov


Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.

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