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J Neuroendocrinol. 2005 Aug;17(8):519-25.

Kisspeptins: regulators of metastasis and the hypothalamic-pituitary-gonadal axis.

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  • 1Department of Metabolic Medicine, Imperial College Faculty of Medicine, Hammersmith Campus, London, UK. k.g.murphy@imperial.ac.uk

Abstract

The kisspeptins are the peptide products of the KiSS-1 gene and the endogenous agonists for the GPR54 receptor. Although KiSS-1 was initially discovered as a metastasis suppressor gene, recent evidence suggests the kisspeptin/GPR54 system is a key regulator of the reproductive system. Disrupted GPR54 signalling causes hypogonadotrophic hypogonadism in rodents and man. Central or peripheral administration of kisspeptin potently stimulates the hypothalamic-pituitary-gonadal axis, increasing circulating gonadotrophin concentrations in a number of animal models. These effects appear likely to be mediated via the hypothalamic gonadotrophin-releasing hormone system, although kisspeptins may have direct effects on the anterior pituitary gland. Hypothalamic KiSS-1 expression is regulated by circulating sex steroids. The precise physiological role of the kisspeptin system in the regulation of reproductive function remains to be elucidated.

PMID:
16011488
[PubMed - indexed for MEDLINE]
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