J Am Chem Soc. 2005 Jul 20;127(28):10016-7.

Toward cocaine esterase therapeutics.

Rogers CJ, Mee JM, Kaufmann GF, Dickerson TJ, Janda KD.

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The Skaggs Institute for Chemical Biology and Departments of Chemistry and Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Abstract

Cocaine is among the most reinforcing of all drugs of abuse, yet no effective pharmacotherapy is available. Herein, we report the development and characterization of phage-displayed cocaine esterases with pharmacologically relevant kinetic parameters (kcat/Km approximately 104 M-1 s-1).

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PMCID:: PMC1352337

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