Format

Send to:

Choose Destination
See comment in PubMed Commons below
Eur J Pediatr. 1992 Mar;151(3):218-20.

Nutritional vitamin B12 deficiency: two cases detected by routine newborn urinary screening.

Author information

  • 1Department of Paediatrics, Hôpital Sainte-Justine, Côte Ste-Catherine, Montréal, Québec, Canada.

Abstract

We describe two asymptomatic newborns with nutritional vitamin B12 deficiency in whom increased urinary methylmalonic acid was detected by routine neonatal screening at 3 weeks of age. Both infants were exclusively breast-fed. One mother suffered from pernicious anaemia, and the other was a strict vegetarian. Both mothers had no clinical or haematological abnormality, aside from a borderline mean corpuscular volume for the vegetarian mother. This report illustrates the early appearance of functional vitamin B12 deficiency in breast-fed infants of vitamin B12-depleted mothers. It also demonstrates that urinary methylmalonic acid measurement is a sensitive indicator of tissue vitamin B12 deficiency.

PMID:
1601016
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk