RNAi: the nuts and bolts of the RISC machine

Cell. 2005 Jul 15;122(1):17-20. doi: 10.1016/j.cell.2005.06.023.

Abstract

Research on RNA interference and microRNA pathways continues to accelerate. Combinations of biochemical, genetic, and structural approaches are providing new insights into the mechanism by which small, approximately 21 nt long RNAs find their way into the RISC effector complexes and how the RISCs execute their mission of RNA-guided posttranscriptional gene silencing.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / metabolism
  • Gene Silencing
  • MicroRNAs / chemistry
  • MicroRNAs / genetics
  • MicroRNAs / physiology*
  • Models, Biological
  • RNA Interference / physiology*
  • RNA-Induced Silencing Complex* / chemistry
  • RNA-Induced Silencing Complex* / genetics
  • RNA-Induced Silencing Complex* / physiology

Substances

  • MicroRNAs
  • RNA-Induced Silencing Complex