Contraction-induced myokine production and release...[Exerc Sport Sci Rev. 2005]

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1: Exerc Sport Sci Rev. 2005 Jul;33(3):114-9. Links

Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?

Febbraio MA, Pedersen BK.

Cellular and Molecular Metabolism Laboratory, RMIT University, Bundoora, Australia.

The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

PMID: 16006818 [PubMed - indexed for MEDLINE]

Beneficial health effects of exercise--the role of IL-6 as a myokine. [Trends Pharmacol Sci. 2007]
The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? [Proc Nutr Soc. 2004]
Role of myokines in exercise and metabolism. [J Appl Physiol. 2007]
Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle. [Endocrinology. 2006]
Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. [Diabetes. 2004]
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Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?

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