Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Phys Med Rehabil. 2005 Jul;86(7):1304-10.

Nonthermal ultrasound and exercise in skeletal muscle regeneration.

Author information

  • 1Sport and Excercise Science Program, Ohio State University, Columbus, OH 43210-1284, USA.

Abstract

OBJECTIVE:

To determine whether continuous nonthermal therapeutic ultrasound (US) and low-intensity exercise (Ex) influence skeletal muscle regeneration after a standardized contusion injury in an animal model.

DESIGN:

Randomized controlled trial with blinded comparisons in a 2 x 2 factorial (US by Ex) design.

SETTING:

Animal care facility and exercise physiology biochemistry laboratory.

ANIMALS:

Twenty male Wistar rats (age, 8 mo) received a reproducible bilateral contusion injury to the gastrocnemius muscles. Ten gastrocnemius muscles from 5 noninjured, nontreated rats provided baseline control data.

INTERVENTIONS:

US (continuous duty cycle, 3 MHz; intensity, 0.1 W/cm2 ; transducer, 1cm2 ; duration, 5 min/d; duty cycle, 100%) and exercise (20 min/d of low-intensity treadmill walking at 14 m/min). Gastrocnemius muscles from injured rats received exercise treatment alone (Ex + NoUS), exercise and US treatment (Ex + US), US treatment alone (NoEx + US), and no treatment (NoEx + NoUS).

MAIN OUTCOME MEASURES:

Ninety-six-hour postinjury muscle mass, contractile protein concentration, fiber cross-sectional area, number of nuclei per fiber, and myonuclear density.

RESULTS:

Myonuclei per fiber were statistically greater in injured than in noninjured gastrocnemius muscle (P < .05). There were no statistical differences (P > .01) among the 4 injured treatment groups for any of the outcome measures chosen as biomarkers of skeletal muscle regeneration.

CONCLUSIONS:

There is no evidence that the specific continuous US and Ex protocols investigated enhanced skeletal muscle regeneration after contusion injury.

PMID:
16003655
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk