Phenylpyrroles, a new chemolibrary virtual screeni...[Bioorg Med Chem Lett. 2005]

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1: Bioorg Med Chem Lett. 2005 Aug 15;15(16):3753-7. Links

Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands.

Paillet-Loilier M, Fabis F, Lepailleur A, Bureau R, Butt-Gueulle S, Dauphin F, Delarue C, Vaudry H, Rault S.

Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, UFR des Sciences Pharmaceutiques, 5, rue Vaubénard 14032 Caen Cedex, France.

Virtual screening studies have identified a series of phenylpyrroles as novel 5-HT7 receptor ligands. The synthesis and the affinity for the 5-HT7 receptor of these phenylpyrroles are described. Some of these compounds exhibited high affinity for the 5-HT7 receptors.

PMID: 16002287 [PubMed - indexed for MEDLINE]

Molecular modeling studies focused on 5-HT7 versus 5-HT1A selectivity. Discovery of novel phenylpyrrole derivatives with high affinity for 5-HT7 receptors. [J Chem Inf Model. 2005]
4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands. [Bioorg Med Chem Lett. 2005]
1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. [Bioorg Med Chem Lett. 2006]
ReviewIn the search for selective ligands of 5-HT5, 5-HT6 and 5-HT7 serotonin receptors. [Pol J Pharmacol. 2002]
ReviewPharmacophore models for metabotropic 5-HT receptor ligands. [Curr Top Med Chem. 2006]

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Phenylpyrroles, a new chemolibrary virtual screening class of 5-HT7 receptor ligands.

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