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J Clin Microbiol. 2005 Jul;43(7):3551-4.

Fatal reactivation of postnatal cytomegalovirus infection with rapid emergence of ganciclovir resistance in an infant after allogeneic stem cell transplantation.

Author information

  • 1Pediatric Bone Marrow Transplant Unit, Charité Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany. sebastian.voigt@charite.de

Abstract

Human cytomegalovirus (HCMV) can cause serious problems after hematopoietic stem cell transplantation. The death of a pediatric transplant recipient after reactivation of a postnatal HCMV infection with bilateral retinitis and pneumonitis is described. Sequencing of the HCMV UL97 region revealed a compartment-specific mutation (H520Q) in urine conferring ganciclovir resistance.

PMID:
16000504
[PubMed - indexed for MEDLINE]
PMCID:
PMC1169106
Free PMC Article

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