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Genome Biol. 2005;6(7):115. Epub 2005 Jun 29.

Conservation anchors in the vertebrate genome.

Author information

  • 1Department of Molecular Genetics, Crown Human Genome Center, Weizmann Institute of Science, Rehovot 76100, Israel.

Abstract

Genomic segments that do not code for proteins yet show high conservation among vertebrates have recently been identified by various computational methodologies. We refer to them as ANCORs (ancestral non-coding conserved regions). The frequency of individual ANCORs within the genome, along with their (correlated) inter-species identity scores, helps in assessing the probability that they function in transcription regulation or RNA coding.

PMID:
15998454
[PubMed - indexed for MEDLINE]
PMCID:
PMC1175977
Free PMC Article

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