Clin Immunol. 2005 Aug;116(2):174-81.

Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection.

Branger J, Leemans JC, Florquin S, Speelman P, Golenbock DT, van der Poll T.

Source

Department of Experimental Internal Medicine, Academic Medical Center, Room F4-222, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. J.Branger@amc.uva.nl

Abstract

Lipopolysaccharide (LPS) binding protein (LBP) facilitates the transfer of LPS of Gram-negative bacteria to the pattern recognition receptor CD14, resulting in activation of immunocompetent cells. LBP can also facilitate the binding of lipoarabinomannan, a major cell wall component of mycobacteria, to immune cells. To determine the role of LBP in the immune response to pulmonary Mycobacterium tuberculosis infection, LBP gene-deficient (-/-) and normal wild-type (WT) mice were intranasally infected with M. tuberculosis. LBP-/- mice displayed a similar survival and mycobacterial outgrowth in lungs and liver, although they demonstrated a reduced lymphocyte recruitment and activation during the early stages of infection. The clearance of pulmonary infection with the non-pathogenic M. smegmatis was also unaltered in LBP-/- mice. These data suggest that LBP does not contribute to an effective host response in M. tuberculosis infection.

PMID:: 15993364; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

KOMP Repository

Miscellaneous

Mouse Genome Informatics (MGI)

Supplemental Content

Save items

Related citations in PubMed

LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia. [Int Immunol. 2004]
LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.
Branger J, Florquin S, Knapp S, Leemans JC, Pater JM, Speelman P, Golenbock DT, van der Poll T. Int Immunol. 2004 Nov; 16(11):1605-11. Epub 2004 Sep 27.
Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo. [J Immunol. 2006]
Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo.
Knapp S, Florquin S, Golenbock DT, van der Poll T. J Immunol. 2006 Mar 1; 176(5):3189-95.
Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology. [J Trauma. 2006]
Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology.
Hemmila MR, Kim J, Sun JM, Cannon J, Arbabi S, Minter RM, Su GL, Remick DG, Wang SC. J Trauma. 2006 Sep; 61(3):598-605; discussion 605-6.
Review Non-LPS targets and actions of LPS binding protein (LBP). [J Endotoxin Res. 2005]
Review Non-LPS targets and actions of LPS binding protein (LBP).
Schröder NW, Schumann RR. J Endotoxin Res. 2005; 11(4):237-42.
Review Fighting infection: the role of lipopolysaccharide binding proteins CD14 and LBP. [Pathobiology. 1999]
Review Fighting infection: the role of lipopolysaccharide binding proteins CD14 and LBP.
Schütt C. Pathobiology. 1999; 67(5-6):227-9.

See reviews... See all...

Cited by 1 PubMed Central article

CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. [Immunology. 2008]
CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis.
Wieland CW, van der Windt GJ, Wiersinga WJ, Florquin S, van der Poll T. Immunology. 2008 Oct; 125(2):272-9. Epub 2008 Apr 3.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Lipopolysaccharide binding protein-deficient mice have a normal defense against ...
Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection.
Clin Immunol. 2005 Aug ;116(2):174-81.

PubMed
Recurrent papular urticaria after varicella immunization in a fifteen-month-old ...
Recurrent papular urticaria after varicella immunization in a fifteen-month-old girl.
Pediatr Infect Dis J. 2005 Mar ;24(3):269-70.

PubMed
A pilot, randomized, double-blinded, placebo-controlled trial of individualized ...
A pilot, randomized, double-blinded, placebo-controlled trial of individualized homeopathy for symptoms of estrogen withdrawal in breast-cancer survivors.
J Altern Complement Med. 2005 Feb ;11(1):13-20.

PubMed
Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesoderm...
Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction.
Development. 2005 Mar ;132(6):1429-42.

PubMed
Inducible nitric oxide synthase in long-term intermittent hypoxia: hypersomnolen...
Inducible nitric oxide synthase in long-term intermittent hypoxia: hypersomnolence and brain injury.
Am J Respir Crit Care Med. 2005 Jun 15 ;171(12):1414-20. Epub 2005 Mar 4 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: