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Expert Opin Investig Drugs. 1999 Aug;8(8):1255-62.

AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury.

Author information

  • 1Department of Medicine, McMaster University Health Sciences Center, Hamilton, ON L8N 2S1, Canada. mrathbon@fhs.csu.mcmaster

Abstract

The synthetic purine 4-[[3-(1,6 dihydro-6-oxo-9-purin-9-yl)-1-oxypropyl] amino] benzoic acid (AIT-082, Neotrofin, leteprinim potassium) possesses several biological properties of note: it stimulates outgrowth of neurites from PC12 cells and neurones, stimulates synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo and enhances of memory in animals and humans. AIT-082 also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of AIT-082 in animal models of acute central nervous system injury. In such cases, AIT-082 probably functions by both acutely reducing glutamate excitotoxicity and, over a longer period, by enhancing neuronal sprouting and functional recovery.

PMID:
15992149
[PubMed]
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