Palmar fasciitis and a polyarthritis syndrome (PFPAS) is an uncommon paraneoplastic syndrome often associated with occult neoplasms, including ovarian and pancreatic carcinomas. A 67-year-old patient with presenting symptoms of PFPAS is reported. Twelve months after onset of the symptoms an ovarian and pancreatic adenocarcinoma was diagnosed synchronously. The spread pattern and other features of the neoplasm indicate that it was a primary pancreatic cancer with ovarian metastasis. Surgical excision of tumor and adjuvant chemotherapy caused remission of symptoms. A literature review of PFPAS and secondary ovarian neoplasms with a pancreatic primary tumor is discussed.