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    Bioorg Med Chem Lett. 2005 Aug 1;15(15):3524-7.

    Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.

    Source

    New England Eye Center, Boston, MA 02111, USA.

    Erratum in

    • Bioorg Med Chem Lett. 2006 May 15;16(10):2822. Al-Ghananeem, Abeer A [corrected to Al-Ghananeem, Abeer M].

    Abstract

    The purpose of this study was to synthesize a novel prodrug of ethacrynic acid (ECA) with short chain polyethylene glycols (PEGs) and codrugs of ECA with the beta-adrenergic blocking agent atenolol (ATL) or timolol (TML) to overcome the adverse effects of ECA and to enhance its physicochemical properties.

    PMID:
    15990301
    [PubMed - indexed for MEDLINE]

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