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Cell. 2005 Jul 1;121(7):963-5.

Life, death, and ubiquitin: taming the mule.

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  • 1Department of Molecular Cell Biology, The Weizmann Institute, Rehovot, Israel.


Ubiquitin-mediated protein degradation is an efficient way for the cell to get rid of unwanted proteins. A key player in this process is the E3 ubiquitin ligase. In this issue of Cell, and describe a new E3 ligase, ARF-BP1/Mule, which targets two very different substrates, p53 and Mcl-1, with completely different cellular outcomes.

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