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Am J Hum Genet. 1992 Jun;50(6):1211-7.

Confirmation of genetic heterogeneity in limb-girdle muscular dystrophy: linkage of an autosomal dominant form to chromosome 5q.

Author information

  • 1Division of Neurology, Duke University Medical Center, Durham, NC 27710.

Abstract

Limb-girdle muscular dystrophy (LGMD) is a clinically and genetically heterogenous group of disorders, with both recessive and dominant forms reported. Recently, a series of recessive LGMD families were linked to chromosome 15q. We report herein the results of our linkage studies in a previously reported large autosomal dominant family. The LGMD gene in this family was localized to chromosome 5q22.3-31.3 by using a series of CA(n) microsatellite repeat markers. Linkage to 15q was excluded. These findings confirm genetic heterogeneity in this clinically diverse syndrome.

PMID:
1598902
[PubMed - indexed for MEDLINE]
PMCID:
PMC1682558
Free PMC Article
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