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Breast Cancer Res. 2005;7(4):R555-62. Epub 2005 May 16.

Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case-control study.

Author information

  • 1Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. rulla.tamimi@channing.harvard.edu

Abstract

INTRODUCTION:

Alcohol consumption is a well-established risk factor for breast cancer. Some studies have suggested that the risk of breast cancer associated with alcohol consumption is greater for women with a history of benign breast disease (BBD). We hypothesized that among women with biopsy-confirmed BBD, recent alcohol consumption would increase the risk of breast cancer in women with proliferative breast disease to a greater extent than in women with nonproliferative breast disease.

METHODS:

We conducted a nested case-control study in the Nurses' Health Study I and II. The cases (n = 282) were women diagnosed with incident breast cancer, with a prior biopsy-confirmed breast disease. The controls (n = 1,223) were participants with a previous BBD biopsy, but without a diagnosis of breast cancer. Pathologists reviewed benign breast biopsy slides in a blinded fashion and classified the BBD as nonproliferative, proliferative without atypia, or atypical hyperplasia, according to standard criteria.

RESULTS:

Women with nonproliferative breast disease consuming > or = 15 g of alcohol per day had a nonsignificant 67% increased risk of breast cancer (odds ratio = 1.67; 95% confidence interval 0.65 to 4.34) compared with nondrinkers. There was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent in women with proliferative BBD than among women with nonproliferative BBD (P for interactio n = 0.20).

CONCLUSION:

Contrary to our a priori hypothesis, there was no evidence that recent alcohol consumption increased the risk of breast cancer to a greater extent among women with proliferative BBD than among women with nonproliferative BBD.

PMID:
15987462
[PubMed - indexed for MEDLINE]
PMCID:
PMC1175067
Free PMC Article
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