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Org Lett. 2005 Jul 7;7(14):3123-5.

Phosphine oxides as preligands in ruthenium-catalyzed arylations via C-H bond functionalization using aryl chlorides.

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  • 1Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Germany.


[reaction: see text] The use of air-stable, electron-rich phosphine oxides as preligands allows for unprecedented general ruthenium-catalyzed arylation reactions of pyridines and imines through C-H-bond activation using aryl chlorides. The catalytic system derived from a sterically hindered adamantyl-substituted phosphine oxide proves highly efficient and tolerates a number of important functional groups.

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