Science. 1992 May 29;256(5061):1331-3.

Identification of a prenylation site in delta virus large antigen.

Glenn JS, Watson JA, Havel CM, White JM.

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Department of Pharmacology, University of California, San Francisco 94143-0450.

Abstract

During replication, hepatitis delta virus (HDV) switches from production of small to large delta antigen. Both antigen isoforms have an HDV genome binding domain and are packaged into hepatitis B virus (HBV)-derived envelopes but differ at their carboxy termini. The large antigen was shown to contain a terminal CXXX box and undergo prenylation. The large, but not the small, antigen formed secreted particles when expressed singly with HBV surface antigen. Mutation of Cys211 in the CXXX box of the large antigen abolished both prenylation and particle formation, suggesting that this site is important for virion morphogenesis.

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Ann Plast Surg. 2006 Apr;56(4):465-7.

PMID:: 1598578; [PubMed - indexed for MEDLINE]

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Identification of a prenylation site in delta virus large antigen.

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