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    Biometals. 2005 Jun;18(3):207-12.

    Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats.

    Pushpalatha T, Srinivas M, Sreenivasula Reddy P.

    Department of Biotechnology, Sri Venkateswara University, Tirupati - 517 502, India.

    Sodium fluoride (NaF) administered orally to adult male rats at a dose level of 4.5 ppm and 9.0 ppm for 75 days caused significant decrease in the body weight, brain index and testicular index. A significant decrease in sperm count, sperm motility, sperm viability and sperm function (HOS positive) with increased sperm abnormalities was also observed in NaF-exposed male rats. The activity levels of testicular steroidogenic marker enzymes 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) were significantly decreased in NaF-treated rats indicating decreased steroidogenesis and in turn spermatogenesis in rats exposed to NaF.

    PMID: 15984565 [PubMed - indexed for MEDLINE]

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