The market withdrawal of rofecoxib (Vioxx) in September 2004 was the logical, if long-overdue, result of what has become a major scandal. How can similar situations be avoided in the future? The authorities must of course come to grips with their responsibilities, but caregivers, patients and journalists also have a role to play. This was the theme of the press conference held at Prescrire headquarters after the annual awards ceremony on 20 January 2005