Send to:

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2005 Aug 5;1724(3):228-38.

Progress in analytical imaging of the cell by dynamic secondary ion mass spectrometry (SIMS microscopy).

Author information

  • 1Laboratoire de Microscopie Ionique, Institut Curie Recherche, Bât 112, Centre Universitaire, 91405 Orsay Cedex, France.


This paper reviews the most recent methodological advances in the field of biological imaging using dynamic secondary ion mass spectrometry (SIMS). After a short reminder of the basic principle of SIMS imaging, the latest high-resolution dynamic SIMS equipment is briefly described. This new ion nanoprobe (CAMECA NanoSIMS 50) has a lateral resolution of less than 50 nm with primary Cs+ ion, the ability to detect simultaneously 5 different ions from the same micro-volume and a very good transmission even at high mass resolution (60% at M/DeltaM=5000). Basic considerations related to sample preparation, mass resolution and primary ion implantation are given. The decisive capability of this new instrument, and more generally of high-resolution dynamic SIMS imaging in biology, are illustrated with the most recent examples of utilization.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk