HLA-Cw*1210 and -Cw*080102 were identified in Taiwan populations using reverse-line SSO typing method. Sequencing showed that HLA-Cw*1210 and -Cw*120201/02 were identical at exon 2 but differed at exon 3 with three nucleotide substitutions at codons 99 and 105 and an amino acid change from tyrosine to phenylalanine at codon 99. Also, allele HLA-Cw*080102 differed from HLA-Cw*080101 in exon 3 by a single synonymous nucleotide transition at codon 99. HLA-Cw*080102 was found only in the Puyuma indigenous tribe of Taiwan and had a frequency of 5%. Interestingly, nucleotide substitutions of HLA-Cw*1210 and -Cw*080102 were located in a noticeably heterogeneous region of the 5' end of exon 3, where similar substitution motifs are frequently found in other HLA-C alleles, therefore suggesting preferential gene conversion in this region.