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Chembiochem. 2005 Jul;6(7):1234-41.

High-throughput evaluation of antioxidant and pro-oxidant activities of polyphenols with thymidine protection assays.

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  • 1Service de Marquage Moléculaire et de Chimie Bio-Organique, DBJC/DSV, CEA Saclay, 91191 Gif sur Yvette Cedex, France.


A recently reported high-throughput screening strategy has been applied to the rapid selection of new water-soluble antioxidants that display strong protective activities. Based on a competitive immunoassay, a triple-screening procedure was used to evaluate the ability of different compounds to protect thymidine under different oxidative stresses. The pro-oxidant effect of norbadione A in the presence of iron was observed, while some pulvinic acid derivatives proved strongly protective during gamma radiolysis, UV irradiation, and Fenton-like oxidation.

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