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Can J Microbiol. 2005 Apr;51(4):283-6.

Growth rate and oxygen regulate the interactions of group B Streptococcus with polarized respiratory epithelial cells.

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  • 1Channing Laboratory, Department of Medicine, Breigham & Women's Hospital, Harvard Med School, 181 Longwood Avenue, Boston, MA 02115, USA.


We investigated growth conditions that regulate the ability of group B Streptococcus (GBS) to attach to, invade, and translocate through polarized human respiratory epithelial cells (RECs). GBS grown in a chemostat at a fast cell mass doubling time (t(d) = 1.8 h), invaded RECs from both the apical and basolateral surfaces in higher numbers compared with those held at a t(d) = 11 h. With the exception of adherence from the basolateral surface, GBS reached peak adherence to, invasion of, and translocation through RECs when held at the fast t(d) with 15% dissolved oxygen compared with 0% dissolved oxygen. Growth rate and oxygen level strongly influence the interaction of GBS with polarized RECs and likely GBS pathogenicity.

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