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Biochim Biophys Acta. 2005 Jul 10;1744(3):406-14. Epub 2005 Mar 22.

Golgi structure in stress sensing and apoptosis.

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  • 1Department of Cell Biology, Johns Hopkins University School of Medicine, 725 Wolfe St., Baltimore, MD 21205, United States.

Abstract

The Golgi complex in mammalian cells is composed of polarized stacks of flattened cisternal membranes. Stacks are connected by tubules forming a reticular network of membranes closely associated with the microtubule-organizing center. While the Golgi structure is important for the efficient processing of secretory cargo, the organization of the mammalian Golgi complex may indicate potential functions in addition to the processing and sorting of cargo. Similar to the endoplasmic reticulum stress response pathway, the Golgi complex may initiate signaling pathways to alleviate stress, and if irreparable, trigger apoptosis. Here, we review recent experimental evidence suggesting that the elaborate structure of the Golgi complex in mammalian cells may have evolved to sense and transduce stress signals.

PMID:
15979510
[PubMed - indexed for MEDLINE]
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