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Trends Genet. 2005 Aug;21(8):466-75.

Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping.

Author information

  • 1Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
  • 2NASA ARC

Abstract

Traditional microarrays use probes complementary to known genes to quantitate the differential gene expression between two or more conditions. Genomic tiling microarray experiments differ in that probes that span a genomic region at regular intervals are used to detect the presence or absence of transcription. This difference means the same sets of biases and the methods for addressing them are unlikely to be relevant to both types of experiment. We introduce the informatics challenges arising in the analysis of tiling microarray experiments as open problems to the scientific community and present initial approaches for the analysis of this nascent technology.

PMID:
15979196
[PubMed - indexed for MEDLINE]
PMCID:
PMC1855044
Free PMC Article

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