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Trends Genet. 2005 Aug;21(8):436-40.

Striking nucleotide frequency pattern at the borders of highly conserved vertebrate non-coding sequences.

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  • 1MRC Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge CB10 1SB, UK.


In a recent study, 1373 highly conserved non-coding elements (CNEs) were detected by aligning the human and Takifugu rubripes (Fugu) genomes. The remarkable degree of sequence conservation in CNEs compared with their surroundings suggested comparing the base composition within CNEs with their 5' and 3' flanking regions. The analysis reveals a novel, sharp and distinct signal of nucleotide frequency bias precisely at the border between CNEs and flanking regions.

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