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Leuk Res. 2005 Aug;29(8):975-9. Epub 2005 Mar 2.

Idiopathic hypereosinophilic syndrome: a case evolving in B-lymphoblastic lymphoma.

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  • 1Dipartimento di Medicina Interna, Facoltà di Medicina e Chirurgia, University Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.


Idiopathic hypereosinophilic syndrome (HES) is a rare disease characterized by tissue involvement and organ dysfunction due to abnormal eosinophil proliferation. Evolution of HES into myeloid or T-cell malignancies has been frequently reported. Here, we describe a case of HES that preceded the occurrence of a high-grade B-lymphoblastic lymphoma in which clonal evolution has been demonstrated at the molecular level.

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