Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2005 Aug;17(4):415-22.

Autophagosomes: biogenesis from scratch?

Author information

  • 1Life Sciences Institute and Departments of Molecular, Cellular and Developmental Biology and of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

To survive extreme environmental conditions, and in response to certain developmental and pathological situations, eukaryotic organisms employ the catabolic process of autophagy. This degradative pathway allows cells to eliminate large portions of the cytoplasm, from aberrant protein aggregates to superfluous or damaged organelles and even entire organisms such as invading bacteria. Structures targeted for destruction are sequestered into large double-membrane vesicles called autophagosomes and then delivered into the interior of the lysosome or vacuole, where they are consumed by resident hydrolases. Autophagosome formation during selective autophagy is dependent upon the cargoes, and in all cases seems to involve expansion of the sequestering membrane.

PMID:
15978794
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk