Matrigel: basement membrane matrix with biological...[Semin Cancer Biol. 2005]

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1: Semin Cancer Biol. 2005 Oct;15(5):378-86. Links

Matrigel: basement membrane matrix with biological activity.

Kleinman HK, Martin GR.

NIH, NIDCR, 30/433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892-4370, USA. hkleinman@dir.nidcr.nih.gov

The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain all of the components present in basement and to be very biologically active. This extract, termed Matrigel, Cultrex, or EHS matrix, promotes cell differentiation, and is used to measure the invasive activity of tumor cells. In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth.

PMID: 15975825 [PubMed - indexed for MEDLINE]

Reorganization of structural proteins in vascular smooth muscle cells grown in collagen gel and basement membrane matrices (Matrigel): a comparison with their in situ counterparts. [J Struct Biol. 2001]
Preparation of basement membrane components from EHS tumors. [Curr Protoc Cell Biol. 2001]
Inhibition of human corneal epithelial production of fibrotic mediator TGF-beta2 by basement membrane-like extracellular matrix. [Invest Ophthalmol Vis Sci. 2007]
ReviewInvasion assays. [Curr Protoc Cell Biol. 2001]
ReviewEffect of Matrigel on adenoid cystic carcinoma cell line differentiation. [Int J Exp Pathol. 2006]

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Matrigel: basement membrane matrix with biological activity.

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