Arch Pharm Res. 2005 May;28(5):557-60.

Fungicidal effect of resveratrol on human infectious fungi.

Jung HJ, Hwang IA, Sung WS, Kang H, Kang BS, Seu YB, Lee DG.

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Department of Microbiology, College of Natural Sciences, Kyungpook National University, Taegu 702-701, Korea.

Abstract

Resveratrol, a phenolic antioxidant found in grapes, has been known to mediate various biological activities on the human body. In the present study, we tested the antifungal activity of resveratrol against human pathogenic fungi before carrying out further studies to elucidate the antifungal mechanism(s) of resveratrol. Resveratrol displayed potent antifungal activity against human pathogenic fungi at concentration levels of 10-20 microg/mL. Furthermore, time-kill curve exhibited fungicidal effect of resveratrol on C. albicans, but the compound had no hemolytic activity against human erythrocytes. The destruction of C. albicans cells by resveratrol was confirmed by scanning electron microscopy. These results suggest that resveratrol could be employed as a therapeutic agent to treat fungal infections of humans.

PMID:: 15974442; [PubMed - indexed for MEDLINE]

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