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Nat Methods. 2005 Jul;2(7):511-3.

Ultrahigh density microarrays of solid samples.

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  • 1Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University Medical Center, NRB E504, 3970 Reservoir Rd. NW, Washington, DC 20057-1469, USA.


We present a sectioning and bonding technology to make ultrahigh density microarrays of solid samples, cutting edge matrix assembly (CEMA). Maximized array density is achieved by a scaffold-free, self-supporting construction with rectangular array features that are incrementally scalable. This platform technology facilitates arrays of >10,000 tissue features on a standard glass slide, inclusion of unique sample identifiers for improved manual or automated tracking, and oriented arraying of stratified or polarized samples.

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