Graefes Arch Clin Exp Ophthalmol. 1992;230(3):240-2.

Galactitol is not a cause of senile cataract.

Arola H, Sillanaukee P, Aine E, Koivula T, Isokoski M.

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Department of Public Health, University of Tampere, Finland.

Abstract

It has been postulated that the accumulation of sugar alcohol, galactitol, from milk induces cataract in the eye lens through an osmotic mechanism. In this study the concentrations of galactitol and other sugar alcohols (sorbitol, mannitol and inositol) were measured by sensitive gas chromatography in the lenses of 15 patients operated on for senile idiopathic cataracts and in 14 clear lenses removed at autopsy. Large amounts of inositol (mean +/- SD, 4.1 +/- 3.1 vs 4.7 +/- 3.0 mumol/g lens wet weight) and small amounts of mannitol and sorbitol were detected in both study groups. Galactitol levels remained clearly below the detection limit (2 nmol/g) in all lenses. It seems unlikely that senile cataract is a result of the accumulation of galactitol in the eye lens.

PMID:: 1597290; [PubMed - indexed for MEDLINE]

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The effects of 5% and 25% galactose diets on lens polyols, glutathione and protein glycation in male and female pigs. [Curr Eye Res. 1989]
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