Display Settings:


Send to:

Choose Destination
Fitoterapia. 2005 Sep;76(6):508-13.

Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense.

Author information

  • 1Department of Psychobiology, Neurophysiology Laboratory, Federal University of São Paulo, Rua Botucatu, 862, 5 andar, 04023-900, São Paulo, Brazil. Guistos@lycos.com


The hydroalcoholic extract of Equisetum arvense (HAE) tested at the doses of 200 and 400 mg/kg showed a significant activity on the open-field, enhanced the number of falls in the rota-rod reducing the time of permanence in the bar and increased the sleeping time (46% and 74%) in the barbiturate-induced sleeping time. In the pentylenetetrazole-seizure, it increased the first convulsion latency, diminished the severity of convulsions, reduced the percentage of animals which developed convulsion (50% and 25%) and protected animals from death. On the contrary, in the elevated plus maze, the doses 50, 100 and 150 mg/kg did not affect the evaluated parameters. Thus, HAE presented anticonvulsant and sedative effects. Phytochemical analysis detected the presence of tannins, saponins, sterols and flavonoids.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk