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Ann Intern Med. 2005 Jun 21;142(12 Pt 1):963-7.

The clinical course of patients with idiopathic pulmonary fibrosis.

Author information

  • 1University of Michigan, Ann Arbor, Michigan 48109, USA. fmartine@med.umich.edu

Abstract

BACKGROUND:

Prospective data defining the clinical course in idiopathic pulmonary fibrosis (IPF) are sparse.

OBJECTIVE:

To analyze the clinical course of patients with mild to moderate IPF.

DESIGN:

Analysis of data from the placebo group of a randomized, controlled trial evaluating interferon-gamma1b.

SETTING:

Academic and community medical centers.

PATIENTS:

168 patients in the placebo group of a trial evaluating interferon-gamma1b.

MEASUREMENTS:

Measures of physiology and dyspnea assessed at 12-week intervals; hospitalizations; and the pace of deterioration and cause of death over a median period of 76 weeks.

RESULTS:

Physiologic variables changed minimally during the study. However, 23% of patients required hospitalization for a respiratory disorder and 21% died. Idiopathic pulmonary fibrosis was the primary cause of death in 89% of patients who died, and an apparent acute clinical deterioration preceded death in 47% of these patients.

LIMITATIONS:

The instrument used to define the pace of deterioration and cause of death was applied retrospectively.

CONCLUSIONS:

Recognition of the common occurrence of acute fatal deterioration in patients with mild to moderate IPF has important implications for monitoring patients and supports early referral for lung transplantation.

Comment in

PMID:
15968010
[PubMed - indexed for MEDLINE]
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