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Nat Neurosci. 2005 Jul;8(7):858-9.

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine.

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  • 1Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka 565-0874, Japan.


Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A1 and A2A receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg(-1) increased wakefulness in both wild-type mice and A1 receptor knockout mice, but not in A2A receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A2A receptors.

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