Abstract
Gluten sensitivity can manifest with ataxia. The metabolic status of the cerebellum was investigated in 15 patients with gluten ataxia and 10 controls using proton MR spectroscopy. Significant differences were present in mean N-acetyl aspartate levels at short echo time and N-acetyl aspartate/choline ratios at long echo time between the patient and control groups. These data support the hypothesis that cerebellar neuronal physiology differs between patients with gluten ataxia and healthy controls.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / analysis
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Celiac Disease / diagnosis*
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Celiac Disease / physiopathology
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Cerebellar Ataxia / diagnosis*
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Cerebellar Ataxia / physiopathology
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Cerebellar Nuclei / pathology
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Cerebellar Nuclei / physiopathology
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Cerebellum / pathology
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Cerebellum / physiopathology*
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Choline / analysis
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Creatine / analysis
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Dominance, Cerebral / physiology
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Energy Metabolism / physiology
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Female
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Humans
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Image Enhancement*
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Image Processing, Computer-Assisted*
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Inositol / analysis
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Magnetic Resonance Imaging*
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Magnetic Resonance Spectroscopy*
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Male
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Middle Aged
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Neuroglia / pathology
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Neuroglia / physiology
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Neurons / pathology
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Neurons / physiology
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Reference Values
Substances
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Aspartic Acid
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Inositol
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N-acetylaspartate
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Creatine
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Choline